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KMID : 0811720090130060431
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Korean Journal of Physiology & Pharmacology
2009 Volume.13 No. 6 p.431 ~ p.436
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Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase
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Lee Kwon-Ho
Chang Seok-Jong
Cho Eun-Jung
Jeon Byeong-Hwa
Kim Hyo-Shin
Park Jin-Bong
Lee Ji-Young
Joo Hee-Kyoung
Cho Chung-Hyun
Lee Sang-Ki
Lee Eun-Ji
Park Myoung-Soo
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Abstract
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The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred in a concentration- and time-dependent manner. However, Ref-1 overexpression with AdRef-1 significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen peroxide elevation in the endothelial cells. Pb exposure induced the downregulation of catalase, it was inhibited by the Ref-1 overexpression in the endothelial cells. Taken together, our data suggests that the overexpression of Ref-1 inhibited Pb-induced cell death via the upregulation of catalase in the cultured endothelial cells.
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KEYWORD
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Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1), Lead, Cell death, Endothelial cells, Catalase
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